Biosynthesis; Clavulanic acid; Proteomics; Regulation; Secondary metabolism; Streptomyces clavuligerus; iTRAQ

Proteomics analysis of global regulatory cascades involved in clavulanic acid production and morphological development in Streptomyces clavuligerus

The genus Streptomyces comprises bacteria that undergo a complex developmental life cycle and produce many metabolites of importance to industry and medicine. Streptomyces clavuligerus produces the β-lactamase inhibitor clavulanic acid, which is used …