The proposed project involves an interdisciplinary effort combining the fields of mathematical modeling, control theory and applied cancer research. In this project nonlinear programming will be applied to reconstruct or modify a mathematical model that describes how cancer chemotherapy may affect a tumor. Numerical simulations will then be performed and compared to experimental results. Once a satisfactory degree of concordance exists between simulated and experimental results, the resulting model will be modified to accommodate parameters introduced by the immunotargeting approach. This approach involves a more specific delivery of the drug to the cancer site using monoclonal antibody carriers recognizing markers expressed preferentially on the targeted cancer cells, thus increasing the efficacy of chemotherapeutic treatment.